3D-Chain is an open-source protocol based on collections of smart contracts which aims to become the key ecosystem for manufacturers, designers and customers. It provides a coordinated decentralized network based on 3D Printing technology and will expand to other manufacturing environments. Within this framework, the benefits of manufacturing and 3D Printing become a global common infrastructure for all. Anyone can access the network, become a stakeholder in its development, add a fabrication technology (e.g. 3D Printer) to 3D-Chain’s ecosystem, add a new design or customize existing one, and receive network payment tokens in exchange. Moreover, demand for personalized design is exponentially growing every year and soon dominate the manufacturing and the economy since personalized items are more appealing to customers than mass-produce items. However, manufacturing new items and personalized them are very expensive and time-consuming. 3D-Chain facilitates the mass customization.